An Overview on Synthetic Hallucinogens

an overview on synthetic hallucinogens

Synthetic hallucinogens are manmade alternatives to substances like lysergic acid diethylamide (LSD) and “magic mushrooms.” While many hallucinogens are derived from natural substances like fungus, synthetic hallucinogens are not, though they do produce similar effects. Synthetic hallucinogens are closer to amphetamines than they are to natural-based hallucinogens from a chemical standpoint.

Most synthetic hallucinogens are classified as N-methoxybenzyl (NBOMe) and are colloquially referred to as “N-bombs.” The original function of these synthetic hallucinogens was to help map the serotonin receptors in the brain, but eventually, people began to use them recreationally. There are many different kinds of synthetic hallucinogens, as even slight alterations to their chemical makeup create new varieties. This is common throughout the designer drug market.


The abuse rates of synthetic hallucinogens are difficult to pin down, according to the DEA, but the 2013 National Survey on Drug Use and Health found that more than 200,000 people in the United States (12 years and older) reported using a hallucinogenic substance in the past month.

Hallucinogen use can begin at an early age. A 2016 survey showed that nearly 2 percent of 8th graders surveyed reported using a hallucinogen at least once in their lifetime. That number more than tripled when it came to high school seniors. More than 6 percent of seniors reported using a hallucinogen in the past year. These statistics include both natural and synthetic hallucinogens, but the exact percentage of synthetic hallucinogens is unknown.

In the 2015 National Survey on Drug Use and Health, more than 16 percent of adults aged 26 or older reported using a hallucinogen at least once while less than 1 percent reported using one in the past year. In the 18-25 age group, about 18 percent reported using at least once in their lifetime; use in the past year was reported by 7 percent of those surveyed. This would indicate that hallucinogen use is more popular among younger people and tapers off with age.

Effects of Synthetic Hallucinogens

Hallucinogens affect the brain by interfering with serotonin, according to the National Institute on Drug Abuse (NIDA). Serotonin regulates a person’s mood, so changes in mood are common among hallucinogen users. Sensory perception is often altered as well as a result of the drug’s effect on serotonin. Serotonin also regulates muscle control and body temperature, so fluctuations of both can occur while under the influence of a hallucinogen. Sexual behavior and hunger may also be affected.

The effects of hallucinogens can take hold within a half-hour and last many hours in certain cases. Intensity of the effects usually vary upon dose, according to the Drug Enforcement Administration (DEA). Common short-term effects include:

  • Hallucinations
  • Rapid heart rate
  • Intense sensory perception
  • Altered sense of time

Some hallucinogens may bring on other symptoms in the short-term, such as:

  • Elevated blood pressure
  • Difficulty sleeping
  • Relaxation
  • Detachment
  • Decreased appetite
  • Loss of coordination
  • Sweating
  • Panic
  • Paranoia
  • Disordered thinking

Long-term effects with continued use can be dire. Kidney problems, bladder issues, and memory impairment are possible. Though it is rare, some people develop hallucinogen persisting perception disorder (HPPD). HPPD includes visual disturbances even when an individual is not under the influence of a hallucinogen. Some people refer to instances of this condition as “flashbacks.” Depression is another long-term effect associated with synthetic hallucinogen use.

Synthetic Hallucinogen Abuse

Some symptoms of synthetic hallucinogen abuse are:

  • Irrational behavior
  • Increased anxiety
  • Paranoia
  • Altered sense of touch, sight, or hearing
  • Mood swings

Abuse of synthetic hallucinogens can be very dangerous, particularly since users often don’t know what they are actually getting when they purchase the drugs. Synthetic hallucinogens appear to be more dangerous than natural-based substances, as they can cause cardiac arrest and other serious medical conditions that are not commonly associated with drugs like LSD and psilocybin mushrooms. Some synthetic hallucinogens can cause seizures, coma, and even death. In addition, accidental injury is not uncommon among people under the influence of hallucinogens.

Use of synthetic hallucinogens can result in overdose. According to MedScape, in 2014, synthetic hallucinogens were being passed off as LSD; users took the substance as if it were LSD, and this resulted in deaths and other serious health problems. That same year, an individual who was unknowingly under the influence of a synthetic hallucinogen attempted to take his own life, according to the Journal of Psychoactive Drugs.

Addiction and Withdrawal

According to NIDA, some hallucinogens, particularly synthetic versions, can be addictive. Prolonged use may result in serious physical dependence, and withdrawal will then occur when a physically dependent person stops taking the drugs. Such individuals can become paranoid and even psychotic. It is not uncommon for a person going through synthetic hallucinogen withdrawal to experience bouts with extreme panic, and they may even begin to exhibit suicidal thinking and/or behavior.

It’s important that detox is done in a medical facility where clients can be consistently monitored by professionals. This ensures the safety of all involved and increases the likelihood that individuals will make it through detox without relapsing back to substance abuse.

Treatment for Synthetic Hallucinogen Abuse

treatment for synthetic hallucinogen abuse

According to NIDA, there are currently no medications available to aid in the treatment of hallucinogen addiction. More research is needed on the matter to develop treatment strategies, but NIDA asserts that behavioral therapies can be helpful.

One of the most prevalent forms of therapy in treating substance abuse and addiction is Cognitive Behavioral Therapy (CBT), and this form of therapy can be effective in treating addiction to synthetic hallucinogens. CBT has been lauded for its ability to give individuals struggling with addiction tools to cope with their addiction that will sustain them into ongoing recovery.

CBT looks to define the connections and relationships between an individual’s feelings, thoughts and behaviors. These three factors are often connected in how they affect an individual’s abuse of drugs. Negative thoughts and feelings can result in stress, which is one of the major triggers for drug use. Drugs are used by many to cope with stress and anxiety. CBT aims to teach an individual new coping mechanisms and attempts to help them anticipate problems that may arise in the future while providing them with realistic solutions. As a result, CBT has seen a lot of success in treating substance abuse.

One specific type of Cognitive Behavioral Therapy is Dialectical Behavior Therapy (DBT). Originally developed to help suicidal individuals who had been diagnosed with borderline personality disorder, DBT has become an accepted and championed form of therapy for a variety of issues, substance abuse included. DBT can feature a multitude of different settings in which an individual participates in therapy. They may partake in DBT in a group setting to learn new skills, individual therapy to increase their motivation, or therapy with multiple therapists in severe cases.

DBT teaches people to be more mindful and aware of their current surroundings, and the ability to tolerate difficult situations is a key component of this therapy. Being able to regulate one’s emotions is also something commonly taught in DBT. All of these things can be effective tools in the pursuit of long-term recovery.

In many cases, complementary or alternative therapies can be useful. Complementary therapies can feature a variety of activities that are considered to be good for the wellbeing of an individual recovering from addiction. Yoga, meditation, homeopathy, and other holistic pursuits can boost the mental and physical wellness of a person and help them develop new, productive habits going forward. While these therapies shouldn’t be the primary method of care, they can complement a traditional, evidence-based treatment plan.

It is never too late to get help for addiction. Call us today at where an admissions navigator will hear your story and help you determine the best treatment for you or your loved one. Desert Hope Treatment Center, American Addiction Centers’ drug recovery center in Las Vegas, offers a comprehensive addiction treatment program. Call us today to find out more.

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